The menopause transition, also known as perimenopause, is the time leading up to menopause when a woman’s menstrual cycles become irregular and eventually stop. It is a time of significant hormonal changes in the body, and it is associated with a range of physical and emotional symptoms. Bipolar disorder is a mental health condition that causes extreme changes in mood, energy, and activity levels. Women with bipolar disorder may have unique considerations during the menopause transition. The hormonal changes of menopause can affect the symptoms of bipolar disorder and can make it more difficult to manage the condition. Oestrogen plays a role in the regulation of the chemicals and processes in the brain that is involved in mood and emotion. The decline in oestrogen levels during menopause can affect the symptoms of bipolar disorder, and some women may experience changes in their mood and behavior during the menopause transition. Additionally, the symptoms of menopause, such as hot flushes and night sweats, can trigger or worsen the symptoms of bipolar disorder. The sleep disturbances, mood changes, and irritability of menopause can also affect the symptoms of bipolar disorder. It is important for women with bipolar disorder to discuss their symptoms and treatment options with a healthcare provider during the menopause transition. This can include adjusting medication and management plans to account for the potential effects of menopause on bipolar disorder. Additionally, women with bipolar disorder can manage their symptoms during the menopause transition by maintaining a healthy and balanced diet, staying hydrated, getting regular exercise, and practicing relaxation techniques to manage stress and improve sleep. It is also important to continue regular therapy and support during this time.